The Phillips & Silverstein model of NMDA-mediated coordination deficits provides a useful heuristic for the study of schizophrenic cognition. However, the model does not specifically account for the development of schizophrenia-spectrum disorders. The P&S model is compared to Meehl's seminal model of schizotaxia, schizotypy, and schizophrenia, as well as the model of schizophrenic cognitive dysfunction posited by McCarley and colleagues.

Introduction Future HIV vaccine efficacy trials with adolescents will need to ensure that participants comprehend study concepts in order to confer true informed assent. A Hepatitis B vaccine trial with adolescents offers valuable opportunity to test youth understanding of vaccine trial requirements in general. Methods Youth reviewed a simplified assent form with study investigators and then completed a comprehension questionnaire. Once enrolled, all youth were tested for HIV and confirmed to be HIV-negative. Results 123 youth completed the questionnaire (mean age=15 (...) years; 63% male; 70% Hispanic). Overall, only 69 (56%) youth answered all six questions correctly. Conclusions Youth enrolled in a Hepatitis B vaccine trial demonstrated variable comprehension of the study design and various methodological concepts, such as treatment group masking. (shrink)

The bitterness and protracted character of the biometrician–Mendelian debate has long aroused the interest of historians of biology. In this paper, we focus on another and much less discussed facet of the controversy: competing interpretations of the inheritance of mental defect. Today, the views of the early Mendelians, such as Charles B. Davenport and Henry H. Goddard, are universally seen to be mistaken. Some historians assume that the Mendelians' errors were exposed by advances in the science of genetics. Others believe (...) that their mistakes could have been identified by contemporaries. Neither interpretation takes account of the fact that the lapses for which the Mendelian eugenicists are now notorious were, in fact, mostly identified at the time by the biometricians David Heron and Karl Pearson. In this paper we ask why their objections had so little impact. We think the answer illustrates an important general point about the social prerequisites for effective scientific critique. (shrink)

Most of us accept that we have special obligations to our family members: to, e.g., our parents, our siblings, and our grandparents. But it is extremely difficult to offer a plausible grounding for such obligations, given the apparent fact that familial relationships are not voluntarily entered. I did not choose to be my mother's daughter or my brother's sister, so why suppose that such facts about me are morally significant? Why suppose that I owe more to my mother or to (...) my brother than natural duty requires that I do for all and any persons? Special obligations appear more problematic the less the relationships that supposedly generate them are akin to the relationship between promiser and promisee, a voluntarily assumed relationship. Thus, for example, special obligations to friends might appear less problematic than do those to family members, because it seems that we voluntarily choose our friends, and, thus, voluntarily choose to bear more for them than natural duty requires. (shrink)

Plasminogen activator inhibitor‐1 (PAI‐1) is a physiological inhibitor of urokinase (uPA), a serine protease known to promote cell migration and invasion. Intuitively, increased levels of PAI‐1 should be beneficial in downregulating uPA activity, particularly in cancer. By contrast, in vivo, increased levels of PAI‐1 are associated with a poor prognosis in breast cancer. This phenomenon is termed the “PAI‐1 paradox”. Many factors are responsible for the upregulation of PAI‐1 in the tumor microenvironment. We hypothesize that there is a breast cancer (...) predisposition to a more aggressive stage when PAI‐1 is upregulated as a consequence of Metabolic Syndrome (MetS). MetS exerts a detrimental effect on the breast tumor microenvironment that supports cancer invasion. People with MetS have an increased risk of coronary heart disease, stroke, peripheral vascular disease and hyperinsulinemia. Recently, MetS has also been identified as a risk factor for breast cancer. We hypothesize the existence of the “PAI‐1 cycle”. Sustained by MetS, adipocytokines alter PAI‐1 expression to promote angiogenesis, tumor‐cell migration and procoagulant microparticle formation from endothelial cells, which generates thrombin and further propagates PAI‐1 synthesis. All of these factors culminate in a chemotherapy‐resistant breast tumor microenvironment. The PAI‐1 cycle may partly explain the PAI‐1 paradox. In this hypothesis paper, we will discuss further how MetS upregulates PAI‐1 and how an increased level of PAI‐1 can be linked to a poor prognosis. BioEssays 29:1029–1038, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The emphasis on individual differences in evolutionary theories is important and has not received adequate attention. Strategic Pluralism makes a major contribution by addressing these issues, but like other evolutionary models (e.g., game theory) does not articulate the specific mechanisms underlying strategy selection. Specification of such mechanisms is an essential next step in the development of these models.

Recent work in social robotics, which is aimed both at creating an artificial intelligence and providing a test-bed for psychological theories of human social development, involves building robots that can learn from ‘face-to-face’ interaction with human beings — as human infants do. The building-blocks of this interaction include the robot’s ‘expressive’ behaviours, for example, facial-expression and head-and-neck gesture. There is here an ideal opportunity to apply Wittgensteinian conceptual analysis to current theoretical and empirical work in the sciences. Wittgenstein’s philosophical psychology (...) is sympathetic to embodied and situated Artificial Intelligence (see Proudfoot, 2002, 2004b), and his discussion of facial-expression is remarkably modern. In this chapter, I explore his approach to facial-expression, using smiling as a representative example, and apply it to the canonical interactive face robot, Cynthia Breazeal’s Kismet (see e.g. Breazeal, 2009, 2002). I assess the claim that Kismet has expressive behaviours, with the aim of generating philosophical insights for AI. (shrink)

Traditional accounts hold that reference consists in a relation between the mind and an object; the relation is effected by a mental act and mediated by internal mental contents (internal representations). Contemporary theories as diverse as Fodor’s [Fodor, J.A., 1987. Psychosemantics: The Problem of Meaning in the Philosophy of Mind. MIT Press, Cambridge, MA] language of thought hypothesis, Dretske’s [Dretske, F., 1988. Explaining Behaviour: Reasons in a World of Causes. MIT Press, Cambridge, MA] informational semantics and Millikan’s [Millikan, R.G., 1984. (...) Language, Thought and Other Biological Categories: New Foundations for Realism. MIT Press, Cambridge, MA] teleosemantics share this act– content–object picture (which was also held by several early modern philosophers, in particular Locke). The core of the traditional view is the thesis that reference and intentionality are relational (‘thesis RR’). Although deeply problematic, RR is entrenched also in psychology, linguistics, cognitive science and Artificial Intelligence. Using for the most part arguments employed by Wittgenstein, we mount a case against RR and advance a deflationary account of reference and intentionality according to which neither is relational. (shrink)

Following Schelling (1960), coordination problems have mainly been considered in a context where agents can achieve a common goal (e.g., rendezvous) only by taking common actions. Dynamic versions of this problem have been studied by Crawford and Haller (1990), Ponssard (1994), and Kramarz (1996). This paper considers an alternative dynamic formulation in which the common goal (dispersion) can only be achieved by agents taking distinct actions. The goal of spatial dispersion has been studied in static models of habitat selection, location (...) or congestion games, and network analysis. Our results show how this goal can be achieved gradually, by indistinguishable non-communicating agents, in a dynamic setting. (shrink)

This _Biographical Dictionary_ provides detailed accounts of the lives, works, influence and reception of thinkers from all the major philosophical schools and traditions of the twentieth-century. This unique volume covers the lives and careers of thinkers from all areas of philosophy - from analytic philosophy to Zen and from formal logic to aesthetics. All the major figures of philosophy, such as Nietzsche, Wittgenstein and Russell are examined and analysed. The scope of the work is not merely restricted to the major (...) figures in western philosophy but also covers in depth a significant number of thinkers from the near and far east and from the non-European Hispanic-language communities. The _Biographical Dictionary_ also includes a number of general entries dealing with important schools of philosophy, such as the Vienna Circle, or currents of thought, such as vitalism. These allow the reader to set the individual biographies in the context of the philosophical history of the period. With entries written by over 100 leading philosophy scholars, the _Biographical Dictionary_ is the most comprehensive survey of twentieth-century thinkers to date. _Structure_ The book is structured alphabetically by philosopher. Each entry is identically structured for ease of access and covers: * nationality * dates and places of birth and death * philosophical style or school * areas of interest * higher education * significant influences * main appointments * main publications * secondary literature * account of intellectual development and main ideas * critical reception and impact At the end of the book a _glossary_ gives accounts of the schools, movements and traditions to which these philosophers belonged, and thorough _indexes_ enable the reader to access the information in several ways: * by nationality * by major areas of contribution to philosophy e.g. aesthetics * by major influences on the thinker concerned e.g. Plato, Kant, Wittgenstein. (shrink)

Using Twin Peaks' Agent Dale Cooper as an example, we explore the paradox of fiction. Employing resources from Aimee Thomasson's account of fictional characters in conjunction with some research on parasocial interaction, we make offer a potential solution for the paradox.

This monograph consists of five parts: (1) introductory material including a conference overview; (2) papers presented at an international symposium on the topic of ethical issues in disability and rehabilitation as a section of the Annual Conference of the Society for Disability Studies; (3) responses to the symposium, prepared by four of the participants; (4) selected additional papers which offer views from perspectives or cultures not represented at the Denver conference; and (5) an annotated international bibliography. Representatives from 10 countries (...) discussed ethical issues and decision making in disability and rehabilitation. Conference papers include: "Genetic Engineering--The New Eugenics? Evolving Medical Attitudes towards the Quality of Life" (Hugh Gallagher);"Description of the Decision-Making Project" (Daryl Evans); "Treatment and Nontreatment Decisions with Respect to Extremely Premature, Very Low Birthweight Infants (500-750g)" (Ernle Young); "Allocation of Resources and Distributive Justice" (John Mather); "Quality Assurance as an Aid to Ethical Decision Making in Disability Management: Lessons from Recent Ethical Issues Involving Disadvantaged Groups in New Zealand" (Peter Gow); "Disability and Ethical Issues: A Point of View from the Netherlands" (Yolan Koster-Dreese); "Who Shall Live or How Shall They Live? Consumer and Professional Perspectives on Treatment/Non-Treatment Decisions" (Joseph Kaufert and Patricia Kaufert); and "Debates across Social Movements on Reproductive Technologies, Genetic Engineering, and Eugenics" (Theresia Degener). Conference commentaries include: "The Meeting of Disability and Bioethics: A Beginning Rapprochement" (Adrienne Asch); "A Plea for More Dialogue: Commentary on Ethics Conference" (Robert Slater); "Healing Our Wounds" (Martha Lentz Walker); "Theories and Values: Ethics and Contrasting Perspectives on Disability" (Harlan Hahn); and "Current Example of Ethical Dilemma" (Susan Lacetti). Selected additional papers include: "High-tech Medicine Is Basic Care" (Frederick Abrams); "Prevention of Disabilities as a Medical Question" (G. Schioler); "The Ethics of Disability Prevention: A Parent's Point of View" (Mrs. J. Baker); "A Reference Matrix for Issues of Life and Personhood" (Mike Miles); "Nazi Scientists and Ethics of Today" (Isabel Wilkerson); "Ethical and Policy Issues in Rehabilitation Medicine (Hastings Center Report)" (Arthur Caplan et al.); and "Differing Approaches to Prevention of Disability and Treatment of Impaired Infants Creates Controversies Worldwide" (Barbara Duncan). (JDD). (shrink)

In the target article, Clark and Fischer argue that little is known about children's perceptions of social robots. By reviewing the existing literature we demonstrate that infants and young children interact with robots in the same ways they do with other social agents. Importantly, we conclude children's understanding that robots are artifacts (e.g., not alive) develops gradually during the preschool years.

Despite external environmental changes in walking, such as manipulating gait speed, previous studies have shown that the underlying muscle synergy structures (synergy weights or vectors) rarely vary. The purpose of this study is to examine if external environmental changes to the walking task influence muscle synergies in children with cerebral palsy (CP) and/or typical development (TD). To identify muscle synergies, we extracted muscle synergies from eight children with CP and eight age-matched TD in three treadmill walking conditions, e.g., baseline (adjusted (...) to individual comfortable walking speed), variable speed (VS), or restricted foot width (RW). Then, we grouped similar muscle synergies using k-mean clustering and discriminant analyses from all datasets of individual synergy structures. Proportion tests exhibited six clusters of muscle synergies predominantly arising from children with CP and four clusters from children with TD. Also, the proportion of muscle synergies was significantly different in four of the CP-preferred clusters across conditions. Specifically, the proportion of the baseline condition was significantly different from VS and RW conditions in one and two clusters, respectively. The proportion was significantly different between VS and RW conditions in four clusters. Cadence and step lengths differed across conditions but not groups which makes the group differences in proportion even more notable. In contrast, step width, while significantly lower in CP, did not differ across conditions. Our findings demonstrate that muscle synergies in children with CP are more sensitive to changes in the external walking environment than in typically developing children. (shrink)

This is the first dictionary dedicated to the work of Jean Baudrillard. It explains and contextualises more than a hundred key concepts, terms, influences and topics within his thought. An essential reference for students and scholars of Baudrillard, it also serves as an authoritative overview of how his ideas have shaped a broad range of disciplines, from art, architecture, film and photography to sociology, philosophy, human geography, media studies and cultural studies. The entries are written by 35 leading Baudrillard specialists (...) from around the world, including Rex Butler, Mike Gane, Gary Genosko, Victoria Grace, Diane Rubenstein and Andrew Wernick. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Writing Anxiety: Christa Wolf’s KindheitsmusterMichael G. Levine (bio)For Diane C.Christa Wolf’s Kindheitsmuster, published in English as Patterns of Childhood, takes very little for granted—least of all the question of beginnings. The novel literally opens with the words of another: “Das Vergangene ist nicht tot; es ist nicht einmal vergangen,” a slightly altered translation of a line from Faulkner’s Requiem for a Nun: “The past is never dead. It’s (...) not even past.” 1 Lacking a proper opening and haunted by the specter of an unmastered and perhaps unmasterable past—of a “model childhood” spent in the East Prussian town of L. during the Third Reich, the text begins by questioning the very possibility of a clean break and a fresh start. This insistent question, raised in a variety of ways throughout the novel, is posed at the outset as a kind of textual stutter, as a perseverating question rehearsed from the beginning—and in lieu of simply beginning—as a series of false starts, as repeated attempts to start over, as a desperate struggle to restart a narrative paralyzed by the anticipation of difficulties still to come. “You lay aside stacks of tentatively filled pages, insert a fresh sheet in the typewriter, and start once again with Chapter 1. As in so many times during the last eighteen months, when you were forced to learn: the difficulties haven’t even begun [die Schwierigkeiten haben noch gar nicht angefangen].” 2 The temporal structure of this passage, found in the second paragraph of the novel, is worth commenting upon, for here the difficult question of how to begin seems to be folded back on itself, turned inside-out, as it were, and reposed as a question of difficulties that apparently have not yet even started. Indeed, only in a text that stammers from the start and begins by beginning over and over again could it be said both that the difficulties have already started and that they have not yet even begun.Already/not yet: such is the split temporal framework of a difficult encounter, of an encounter with difficulties that will never have been confronted as such. 3 The language of confrontation, of squaring off face-to-face, is particularly inappropriate in this context since, as we will see, the difficulties that force “you,” the writer, to begin again are not simply identifiable or avoidable obstacles in the way of writing but, rather, irreducible and irreducibly conflicted aspects of the writing itself. They are what keeps the writing from ever having a self, from ever being one with or self-consciously coming to itself. 4 [End Page 106]While it is tempting to describe Kindheitsmuster as a novel that is self-conscious in the extreme—difficult writing that writes about the difficulties of writing—one should bear in mind that it is a text that repeatedly calls into question the presumed authority and the capacity for self-knowledge of an instance derisively referred to in a passage inexplicably deleted from the English translation as “His Majesty the Ego [Seine Majestät das Ich]” [83]. In an apparent attempt to suspend the privileges usually accorded to—or, rather, autocratically arrogated to itself by—das Ich, the narrator makes a point of scrupulously avoiding the first-person pronoun when referring to herself in the text. (There is, of course, one important exception to this rule toward the end of the novel to which we will return much later.) As was already evident in the passage cited earlier, “You lay aside stacks of tentatively filled pages, insert a fresh sheet in the typewriter, and start once again with Chapter 1,” the narrator employs the second person rather than the first when speaking in the present—as though she could speak of herself at the moment only by speaking to herself. More significant still in this autobiographical novel that deals at length with the narrator’s memories of growing up in Landsberg on the Warthe (now the Polish town of Gorzmploys the second person rather than the first when speaking in the presenerson when referring to the child she used to be.What is one to make of... (shrink)

Excerpt from Zur Psychologie des Asthetischen Genusses Die erste Erfahrung, auf der uberhaupt die Existenz berechtigung einer Wissenschaft wie der Asthetik beruht, ist die, da durch Einwirkung gewisser Objekte auf unsere Sinne ein Wohlgefallen in uns erzeugt wird, das wir unmittelbar und mit ziemlicher Sicherheit von allen anderen Arten des Wohlgefallens unterscheiden. Wenn wir versuchen, diesen zunachst nur gefiihlten Unterschied zu begrifi'licher Klarheit emporzuheben, so bemerken wir, da das asthetische Wohl gefallen durch zwei Eigenschaften charakterisiert und von allen anderen Arten (...) des Glucksgefiihls geschieden ist: erstens knupft es sich nicht an Elementarvorstellungen also ein fache Empfindungen sondern an Vorstellungskomplexe, und zweitens setzt es nicht die reale oder gedachte Erfullung einer zielsetzenden Tatigkeit voraus, sondern hat sein Ziel allein in sich selbst. Durch die erste Bestimmung unterscheidet es sich von sinnlichen Lustgefuhlen, durch die zweite von allen anderen Arten des Wohlgefallens, die wir aus leicht ersieht lichen Grunden als praktisch bezeichnen wollen. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

This book traces the intellectual revolution initiated by Thales in the sixth century BC to its culmination in the metaphysics of Parmenides.

Selected writings, including those of Gʹyu-thog Yon-tan-mgon-po, 1126 to 1202, on the morality of Tibetan medicine.

H G WellsHerbert George Wells, an English writer, was born on 21st 1866 and died on 13 Aug 1946. He was renowned for his works of science fiction especially 'The Time Machine'. He is also referred as 'The Father of Science Fiction'.

Nurses may, and often do, experience moral distress in their careers. This is related to the complicated work environment and the complex nature of ethical situations in everyday nursing practice. The outcomes of moral distress may include psychological and physical symptoms, reduced job satisfaction and even inadequate or inappropriate nursing care. Moral distress can also impact retention of nurses. Although research has grown considerably over the past few decades, there is still a great deal about this topic that we do (...) not know including how to deal well with moral distress. A critical key step is to develop a deeper understanding of relational practice as it pertains to moral distress. In this article, exploration of the experience of moral distress among nurses is guided by the key elements of relational ethics. This ethical approach was chosen because it recognizes that ethical practice is situated in relationships and it acknowledges the importance of the broader environment on influencing ethical action. The findings from this theoretical exploration will provide a theoretical foundation upon which to advance our knowledge about moral distress. (shrink)

According to the Perceptual Symbols Theory of cognition (Barsalou, 1999), modality‐specific simulations underlie the representation of concepts. A strong prediction of this view is that perceptual processing affects conceptual processing. In this study, participants performed a perceptual detection task and a conceptual property‐verification task in alternation. Responses on the property‐verification task were slower for those trials that were preceded by a perceptual trial in a different modality than for those that were preceded by a perceptual trial in the same modality. (...) This finding of a modality‐switch effect across perceptual processing and conceptual processing supports the hypothesis that perceptual and conceptual representations are partially based on the same systems. (shrink)

This essay inquires whether digitally transformed work can be virtuous and under what conditions. It eschews technological determinism in both utopian and dystopian versions, opting for the premise of free human agency. This work is distinctive in adopting an actor-centric and explicitly ethical analysis based on neo-Aristotelian, Catholic social teaching (CST), and MacIntyrean teachings on the virtues. Beginning with an analysis of digital disruption, it identifies the most salient human advantages vis-à-vis technology in digitally transformed work and provides philosophical anthropological (...) explanations for each. It also looks into external, organizational characteristics on both the macro and the micro levels of digitally transformed work, underscoring their ambivalence (efficiency and profits vs. exclusion and exploitation, flexibility and freedom vs. standardization and dependency) and the need to mitigate their polarizing effects for the sake of shared flourishing. The article presents standards for virtuous work according to neo-Aristotelian, CST, and MacIntyrean frames and applies them to digitally transformed work, giving rise to five fundamental principles. These basic guidelines indicate, on one hand, actions to be avoided and, on the other, actions to be pursued, together with their rationales. (shrink)

Using a religious studies methodology, this paper offers a detailed contextual mapping and a structural configuration of how collective violence is justified in Orthodox Christianity. The research design is explanatory, whereby the functional perspectives of doctrine, ethics and worship are all investigated and probed as phenomena of lived religion and orthopraxy. While predominantly initiatory and pedagogical, the paper also proposes a systematic platform for advanced research on this subject, by flagging contexts, themes and areas of inquiry that a researcher might (...) examine in order to untangle the inner workings of the justification of violence in the mind of the Orthodox. Given the ongoing Russian War on Ukraine, relevant samples are drawn from this case.Contribution: This paper outlines the Orthodox Christian justification of violence from the perspectives of doctrine, ethics and ritual and identifies pivotal areas of ambiguity between orthodoxy and orthopraxy. (shrink)

To incorporate medical ethics into clinical practice, it must first be understood and valued by health care professionals. The recognition of this principle led to an expanding and continuing educational effort by the ethics committee of the Vancouver General Hospital. This paper reviews this venture, including some pitfalls and failures, as well as successes. Although we began with consultants, it quickly became apparent that education in medical ethics must reach all health care professionals—and medical students as well. Our greatest successes (...) came in the formative years of a medical career (ie, in medical school and residency training programmes), but other efforts were not wasted, particularly among nurses and other health care professionals.Although this is a personal review of the experience in one institution, the lessons learnt in Vancouver are applicable to the further development of medical ethics in the UK. (shrink)

George Boole published the pamphlet The Mathematical Analysis of Logic in 1847. He believed that logic should belong to a universal mathematics that would cover both quantitative and nonquantitative research. With his pamphlet, Boole signalled an important change in symbolic logic: in contrast with his predecessors, his thinking was exclusively extensional. Notwithstanding the innovations introduced he accepted all traditional Aristotelean syllogisms. Nevertheless, some criticisms have been raised concerning Boole’s view of Aristotelean logic as the solution of algebraic equations. In order (...) to circumvent such criticisms, we show here how Boole’s conclusions may be deduced from the axioms and inference rules proposed in his pamphlet, from which Aristotle’s deductions in Prior Analytics (including those that are completed through an impossibility) can be stated as theorems. We clarify his method for dealing with both universal and particular premises by means of his symbol v and demystify some criticisms concerning the way he expressed particular premises. Boole’s conclusions for some of those premises for which according to Aristotle there is no deduction are also discussed. The deductive system presented here has the potential to provide a new perspective on Boole’s approach to logic in The Mathematical Analysis of Logic. (shrink)

Many sign languages display crosslinguistic consistencies in the use of two iconic aspects of handshape, handshape type and finger group complexity. Handshape type is used systematically in form-meaning pairings (morphology): Handling handshapes (Handling-HSs), representing how objects are handled, tend to be used to express events with an agent (“hand-as-hand” iconicity), and Object handshapes (Object-HSs), representing an object's size/shape, are used more often to express events without an agent (“hand-as-object” iconicity). Second, in the distribution of meaningless properties of form (morphophonology), Object-HSs (...) display higher finger group complexity than Handling-HSs. Some adult homesigners, who have not acquired a signed or spoken language and instead use a self-generated gesture system, exhibit these two properties as well. This study illuminates the development over time of both phenomena for one child homesigner, “Julio,” age 7;4 (years; months) to 12;8. We elicited descriptions of events with and without agents to determine whether morphophonology and morphosyntax can develop without linguistic input during childhood, and whether these structures develop together or independently. Within the time period studied: (1) Julio used handshape type differently in his responses to vignettes with and without an agent; however, he did not exhibit the same pattern that was found previously in signers, adult homesigners, or gesturers: while he was highly likely to use a Handling-HS for events with an agent (82%), he was less likely to use an Object-HS for non-agentive events (49%); i.e., his productions were heavily biased toward Handling-HSs; (2) Julio exhibited higher finger group complexity in Object- than in Handling-HSs, as in the sign language and adult homesigner groups previously studied; and (3) these two dimensions of language developed independently, with phonological structure showing a sign language-like pattern at an earlier age than morphosyntactic structure. We conclude that iconicity alone is not sufficient to explain the development of linguistic structure in homesign systems. Linguistic input is not required for some aspects of phonological structure to emerge in childhood, and while linguistic input is not required for morphology either, it takes time to emerge in homesign. (shrink)

This work provides a text and an extended study of those fragments of Heraclitus' philosophical utterances whose subject is the world as a whole rather than man and his part in it. Professor Kirk discusses fully the fragments which he finds genuine and treats in passing others that were generally accepted as genuine but here considered paraphrased or spurious. In securing his text, Professor Kirk has taken into account all the ancient testimonies, and in his critical work he attached particular (...) importance to the context in which each fragment is set. To each he gives a selective apparatus, a literal translation and and an extended commentary in which problems of textual and philosophical criticism are discussed. Ancient accounts of Heraclitus were inadequate and misleading, and as Kirk wrote, understanding was often hindered by excessive dogmatism and a selective use of the fragments. Professor Kirk's method is critical and objective, and his 1954 work marks a significant advance in the study of Presocratic thought. (shrink)

The human genome project's lasting legacies are the emerging insights into human physiology and disease, and the ascendance of biology as the dominant science of the 21st century. Sequencing revealed that >90% of the human genome is not coding for proteins, as originally thought, but rather is overwhelmingly transcribed into non‐protein coding, or non‐coding, RNAs (ncRNAs). This discovery initially led to the hypothesis that most genomic DNA is “junk”, a term still championed by some geneticists and evolutionary biologists. In contrast, (...) molecular biologists and biochemists studying the vast number of transcripts produced from most of this genome “junk” often surmise that these ncRNAs have biological significance. What gives? This essay contrasts the two opposing, extant viewpoints, aiming to explain their bases, which arise from distinct reference frames of the underlying scientific disciplines. Finally, it aims to reconcile these divergent mindsets in hopes of stimulating synergy between scientific fields. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:John P. Sisk DOCTOR JOHNSON KICKS A STONE Readers OF Boswell's Life ofJohnson will remember the great Doctor's refutation of Bishop Berkeley's idealism. He and Boswell had just come out of a church in Harwich and were discussing the Bishop's "ingenious sophistry to prove the nonexistence of matter." Boswell observed "that though we are satisfied his doctrine is not true, it is impossible to refute it." To mis Johnson (...) responded, "striking his foot with mighty force against a large stone, till he rebounded from it, T refute it thus.'" For Boswell diis was an argument from first principles diat are as fundamental to metaphysics as axioms are to mathematics. To use Johnson's own phrase, it is an argument based on "the experience of mankind" — the ground upon which he confidendy stood when he expressed his disapproval of such other phUosophical contemporaries as Hume, Voltaire, and Rousseau (the latter "a rascal who ought to be hunted out of society"). Or as WalterJackson Bate puts it in TheAchievement ofSamuelJohnson, the first principle ofhis thinking was "To go back to the living and concrete nature of experience."1 Boswell thought Johnson a philosopher, though he admits in a famous passage that his table manners might have suggested otherwise. Apparently G. K. Chesterton thought he had some claim to the term, for he called Johnson's novel Rasselas "a sort of philosophical satire on philosophy." Most likelyJohnson thought ofhimselfas among many other things a philosopher: the humanities had not yet setded snugly into dieir modern compartments. Now, of course, any undergraduate student of philosophy is willing to believe that Johnson's argument against Berkeley isn't worth much (he may be no less willing to believe that the Bishop's argument isn't worth much eitiier). He may also know that in the perspective of die modern physicist Johnson's stone was not as solid as Johnson thought it was — though it is likely he would have thought diis information 65 66Philosophy and Literature no more relevant to die argument dian Thaïes' belief diat all diings are made of water or Pydiagoras' diat all diings are numbers. The important thing was whether a drinker violated die experience of mankind. When the Scotchman Lord Hunderland praised the ancient philosophers for the candor and good humor widi which they disputed with one anotherJohnson would have none of it: "They disputed with good humour upon dieir fanciful dieories," he said, "because diey were not interested in the truth of them." It is not hard to imagine the Doctor's reaction to our own fanciful theories in philosophy, linguistics, and literary criticism. Suppose him at the Mitre Tavern for an evening's defense of die experience of mankind against die ingenious sophistries of a company made up ofJacques Derrida, Geoffrey H. Hartman, Stanley Fish, Michel Foucault, Paul de Man, and Jacques Lacan — the lot of them variously committed to the belief diat the proper job of philosophy is not the pursuit of the truth but the pursuit of die trudi about die pursuit of die truth. Johnson eyes die group warily, expecting the worst. There are too many Frenchmen present, and as he made clear at supper one July evening in the Turk's Head coffee house, French writers are superficial "because they are not scholars, and so proceed upon the mere power of dieir own minds." Nevertheless, the assembled gendemen present their positions: we are all prisoners ofthe total epistemological environment of our age, our episteme; locked linguistically into interpretive communities, we cannot know die text in itself; die proper function of the critic is creative free play, the text being merely a convenient occasion; language, being self-referential, cannot reveal a subject; human agency is a flattering but deceptive myth; transcendent systems of thought are impossible; if literature touches reality anywhere we cannot know it. MeanwhileJohnson, than whom no man ever had "a more ardent love of literature, or a higher respect for it," is in high dudgeon, kicking figurative stones right and left, no real ones being available inside the Mitre. His adversaries observe him with indulgent good humor, amused but not impressed with this crude bourgeois display, having... (shrink)